{"id":23798,"date":"2021-09-27T11:59:23","date_gmt":"2021-09-27T15:59:23","guid":{"rendered":"https:\/\/smarttan.com\/news\/?p=23798"},"modified":"2021-09-27T11:59:23","modified_gmt":"2021-09-27T15:59:23","slug":"further-evidence-that-vitamin-d-might-protect-against-severe-covid-19-disease-and-death","status":"publish","type":"post","link":"https:\/\/news.smarttan.com\/index.php\/further-evidence-that-vitamin-d-might-protect-against-severe-covid-19-disease-and-death\/","title":{"rendered":"Further evidence that vitamin D might protect against severe COVID-19 disease and death"},"content":{"rendered":"

NEWS RELEASE\u00a0

New research from Trinity College Dublin and University of Edinburgh has examined the association between vitamin D and COVID-19, and found that ambient ultraviolet B (UVB) radiation (which is key for vitamin D production in the skin) at an individual\u2019s place of residence in the weeks before COVID-19 infection, was strongly protective against severe disease and death. The paper has been published in the journal\u00a0Scientific Reports<\/a><\/em><\/strong>\u00a0today\u00a0(Wednesday, 15th\u00a0<\/sup>September 2021).<\/strong><\/p>\n

Previous studies have linked vitamin D deficiency with an increased susceptibility to viral and bacterial respiratory infections. Similarly, several observational studies found a strong correlation between vitamin D deficiency and COVID-19, but it could be that these effects are confounded and in fact a result of other factors, such as obesity, older age or chronic illness which are also linked with low vitamin D.<\/p>\n

To overcome this, researchers were able to calculate \u201cgenetically-predicted\u201d vitamin D level, that is not confounded by other demographic, health and lifestyle factors, by using the information from over one hundred genes that determine vitamin D status.<\/p>\n

The Mendelian Randomisation is a particular analytical approach that enabled researchers to investigate whether vitamin D and COVID-19 might be causally linked using genetic data. Few earlier studies attempted this but failed to show a causal link. This could be because UVB radiation sunshine which is the most important source of vitamin D for majority of people was ignored.<\/p>\n

Researchers, for the first time, looked jointly at genetically-predicted and UVB-predicted vitamin D level. Almost half a million individuals in the UK took part in the study, and ambient UVB radiation before COVID-19 infection was individually assessed for each participant. When comparing the two variables, researchers found that correlation with measured vitamin D concentration in the circulation was three-fold stronger for UVB-predicted vitamin D level, compared to genetically-predicted.<\/p>\n

Researchers found\u00a0<\/a>that ambient UVB radiation at an individual\u2019s place of residence preceding COVID-19 infection was strongly and inversely associated with hospitalisation and death.\u00a0This suggests that vitamin D may protect against severe COVID-19 disease and death. Additionally, while the results from the Mendelian Randomisation analysis weren\u2019t conclusive, some indication of a potential causal effect was noted. Because of the relatively weak link between genetically-predicted vitamin D level that is used for Mendelian Randomisation analysis, it is possible that the number of cases in the current study was too small to convincingly determine causal effect, but future larger studies might provide the answer.<\/p>\n

Professor Lina Zgaga<\/strong>,\u00a0Associate Professor in Epidemiology<\/strong>,\u00a0School of Medicine, Trinity College and senior researcher on the study<\/strong>\u00a0said:<\/p>\n

\u201cOur study adds further evidence that vitamin D might protect against severe COVID-19 infection. Conducting a properly designed COVID-19 randomised controlled trial of vitamin D supplementation is critical. Until then, given that vitamin D supplements are safe and cheap, it is definitely advisable to take supplements and protect against vitamin D deficiency, particularly with winter on the horizon.\u201d<\/em><\/p>\n

Professor Evropi Theodoratou, Professor of Cancer Epidemiology and Global Health, University of Edinburgh and<\/strong>\u00a0senior researcher on the study\u00a0<\/strong>said:<\/p>\n

\u201cGiven the lack of highly effective therapies against COVID-19, we think it is important to remain open-minded to emerging results from rigorously conducted studies of vitamin D.\u201d<\/em><\/p>\n

Dr Xue Li, a researcher on the study from Zhejiang University\u00a0<\/strong>said:<\/strong><\/p>\n

\u201cOur study supports the recommendation of vitamin D supplementation for not only the maintenance of bone and muscle health during the lock down, but also the potential benefits in relation to protection from COVID-19.\u201d<\/em><\/p>\n

The full paper:\u00a0An observational and Mendelian randomisation study on vitamin D and COVID-19 risk in UK Biobank\u00a0<\/em>can be read here:\u00a0https:\/\/www.nature.com\/articles\/s41598-021-97679-5<\/a><\/p>\n

 <\/p>\n

SmartTan.com news articles regularly report medical and scientific information to keep you abreast of current events related to UV light. This information is not intended to be used by any party to make unwarranted health claims to promote sunbed usage. Indoor tanning businesses are obligated to communicate a fair and balanced message to all clients about your products and services including the potential risks associated with indoor tanning. Contact your Smart Tan representative to find out more about what you can and can’t say in your tanning salon business.<\/em><\/span><\/p>\n

\u00a9 2021 International Smart Tan Network. All rights reserved.<\/em><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

NEWS RELEASE\u00a015-SEP-2021 New research from Trinity College Dublin and University of Edinburgh has examined the association between vitamin D and COVID-19, and found that ambient ultraviolet B (UVB) radiation (which is key for vitamin D production in the skin) at an individual\u2019s place of residence in the weeks before COVID-19 infection, was strongly protective against […]<\/p>\n","protected":false},"author":2,"featured_media":23799,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-23798","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"yoast_head":"\nFurther evidence that vitamin D might protect against severe COVID-19 disease and death - Smart Tan News<\/title>\n<meta name=\"description\" content=\"NEWS RELEASE\u00a015-SEP-2021 New research from Trinity College Dublin and University of Edinburgh has examined the association between vitamin D and COVID-19, and found that ambient ultraviolet B (UVB) radiation (which is key for vitamin D production in the skin) at an individual\u2019s place of residence in the weeks before COVID-19 infection, was strongly protective against severe disease and death. The paper has been published in the journal\u00a0Scientific Reports\u00a0today\u00a0(Wednesday, 15th\u00a0September 2021). Previous studies have linked vitamin D deficiency with an increased susceptibility to viral and bacterial respiratory infections. Similarly, several observational studies found a strong correlation between vitamin D deficiency and COVID-19, but it could be that these effects are confounded and in fact a result of other factors, such as obesity, older age or chronic illness which are also linked with low vitamin D. To overcome this, researchers were able to calculate \u201cgenetically-predicted\u201d vitamin D level, that is not confounded by other demographic, health and lifestyle factors, by using the information from over one hundred genes that determine vitamin D status. The Mendelian Randomisation is a particular analytical approach that enabled researchers to investigate whether vitamin D and COVID-19 might be causally linked using genetic data. Few earlier studies attempted this but failed to show a causal link. This could be because UVB radiation sunshine which is the most important source of vitamin D for majority of people was ignored. Researchers, for the first time, looked jointly at genetically-predicted and UVB-predicted vitamin D level. Almost half a million individuals in the UK took part in the study, and ambient UVB radiation before COVID-19 infection was individually assessed for each participant. When comparing the two variables, researchers found that correlation with measured vitamin D concentration in the circulation was three-fold stronger for UVB-predicted vitamin D level, compared to genetically-predicted. Researchers found\u00a0that ambient UVB radiation at an individual\u2019s place of residence preceding COVID-19 infection was strongly and inversely associated with hospitalisation and death.\u00a0This suggests that vitamin D may protect against severe COVID-19 disease and death. Additionally, while the results from the Mendelian Randomisation analysis weren\u2019t conclusive, some indication of a potential causal effect was noted. Because of the relatively weak link between genetically-predicted vitamin D level that is used for Mendelian Randomisation analysis, it is possible that the number of cases in the current study was too small to convincingly determine causal effect, but future larger studies might provide the answer. Professor Lina Zgaga,\u00a0Associate Professor in Epidemiology,\u00a0School of Medicine, Trinity College and senior researcher on the study\u00a0said: \u201cOur study adds further evidence that vitamin D might protect against severe COVID-19 infection. Conducting a properly designed COVID-19 randomised controlled trial of vitamin D supplementation is critical. Until then, given that vitamin D supplements are safe and cheap, it is definitely advisable to take supplements and protect against vitamin D deficiency, particularly with winter on the horizon.\u201d Professor Evropi Theodoratou, Professor of Cancer Epidemiology and Global Health, University of Edinburgh and\u00a0senior researcher on the study\u00a0said: \u201cGiven the lack of highly effective therapies against COVID-19, we think it is important to remain open-minded to emerging results from rigorously conducted studies of vitamin D.\u201d Dr Xue Li, a researcher on the study from Zhejiang University\u00a0said: \u201cOur study supports the recommendation of vitamin D supplementation for not only the maintenance of bone and muscle health during the lock down, but also the potential benefits in relation to protection from COVID-19.\u201d The full paper:\u00a0An observational and Mendelian randomisation study on vitamin D and COVID-19 risk in UK Biobank\u00a0can be read here:\u00a0https:\/\/www.nature.com\/articles\/s41598-021-97679-5   SmartTan.com news articles regularly report medical and scientific information to keep you abreast of current events related to UV light. This information is not intended to be used by any party to make unwarranted health claims to promote sunbed usage. Indoor tanning businesses are obligated to communicate a fair and balanced message to all clients about your products and services including the potential risks associated with indoor tanning. Contact your Smart Tan representative to find out more about what you can and can't say in your tanning salon business. \u00a9 2021 International Smart Tan Network. All rights reserved.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/news.smarttan.com\/index.php\/further-evidence-that-vitamin-d-might-protect-against-severe-covid-19-disease-and-death\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Further evidence that vitamin D might protect against severe COVID-19 disease and death - Smart Tan News\" \/>\n<meta property=\"og:description\" content=\"NEWS RELEASE\u00a015-SEP-2021 New research from Trinity College Dublin and University of Edinburgh has examined the association between vitamin D and COVID-19, and found that ambient ultraviolet B (UVB) radiation (which is key for vitamin D production in the skin) at an individual\u2019s place of residence in the weeks before COVID-19 infection, was strongly protective against severe disease and death. The paper has been published in the journal\u00a0Scientific Reports\u00a0today\u00a0(Wednesday, 15th\u00a0September 2021). Previous studies have linked vitamin D deficiency with an increased susceptibility to viral and bacterial respiratory infections. Similarly, several observational studies found a strong correlation between vitamin D deficiency and COVID-19, but it could be that these effects are confounded and in fact a result of other factors, such as obesity, older age or chronic illness which are also linked with low vitamin D. To overcome this, researchers were able to calculate \u201cgenetically-predicted\u201d vitamin D level, that is not confounded by other demographic, health and lifestyle factors, by using the information from over one hundred genes that determine vitamin D status. The Mendelian Randomisation is a particular analytical approach that enabled researchers to investigate whether vitamin D and COVID-19 might be causally linked using genetic data. Few earlier studies attempted this but failed to show a causal link. This could be because UVB radiation sunshine which is the most important source of vitamin D for majority of people was ignored. Researchers, for the first time, looked jointly at genetically-predicted and UVB-predicted vitamin D level. Almost half a million individuals in the UK took part in the study, and ambient UVB radiation before COVID-19 infection was individually assessed for each participant. When comparing the two variables, researchers found that correlation with measured vitamin D concentration in the circulation was three-fold stronger for UVB-predicted vitamin D level, compared to genetically-predicted. Researchers found\u00a0that ambient UVB radiation at an individual\u2019s place of residence preceding COVID-19 infection was strongly and inversely associated with hospitalisation and death.\u00a0This suggests that vitamin D may protect against severe COVID-19 disease and death. Additionally, while the results from the Mendelian Randomisation analysis weren\u2019t conclusive, some indication of a potential causal effect was noted. Because of the relatively weak link between genetically-predicted vitamin D level that is used for Mendelian Randomisation analysis, it is possible that the number of cases in the current study was too small to convincingly determine causal effect, but future larger studies might provide the answer. Professor Lina Zgaga,\u00a0Associate Professor in Epidemiology,\u00a0School of Medicine, Trinity College and senior researcher on the study\u00a0said: \u201cOur study adds further evidence that vitamin D might protect against severe COVID-19 infection. Conducting a properly designed COVID-19 randomised controlled trial of vitamin D supplementation is critical. Until then, given that vitamin D supplements are safe and cheap, it is definitely advisable to take supplements and protect against vitamin D deficiency, particularly with winter on the horizon.\u201d Professor Evropi Theodoratou, Professor of Cancer Epidemiology and Global Health, University of Edinburgh and\u00a0senior researcher on the study\u00a0said: \u201cGiven the lack of highly effective therapies against COVID-19, we think it is important to remain open-minded to emerging results from rigorously conducted studies of vitamin D.\u201d Dr Xue Li, a researcher on the study from Zhejiang University\u00a0said: \u201cOur study supports the recommendation of vitamin D supplementation for not only the maintenance of bone and muscle health during the lock down, but also the potential benefits in relation to protection from COVID-19.\u201d The full paper:\u00a0An observational and Mendelian randomisation study on vitamin D and COVID-19 risk in UK Biobank\u00a0can be read here:\u00a0https:\/\/www.nature.com\/articles\/s41598-021-97679-5   SmartTan.com news articles regularly report medical and scientific information to keep you abreast of current events related to UV light. This information is not intended to be used by any party to make unwarranted health claims to promote sunbed usage. Indoor tanning businesses are obligated to communicate a fair and balanced message to all clients about your products and services including the potential risks associated with indoor tanning. Contact your Smart Tan representative to find out more about what you can and can't say in your tanning salon business. \u00a9 2021 International Smart Tan Network. All rights reserved.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/news.smarttan.com\/index.php\/further-evidence-that-vitamin-d-might-protect-against-severe-covid-19-disease-and-death\/\" \/>\n<meta property=\"og:site_name\" content=\"Smart Tan News\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/SmartTan\" \/>\n<meta property=\"article:published_time\" content=\"2021-09-27T15:59:23+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/news.smarttan.com\/wp-content\/uploads\/2021\/09\/Covid-sun-9-27-21.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1360\" \/>\n\t<meta property=\"og:image:height\" content=\"1000\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"smarttannews\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@SmartTan\" \/>\n<meta name=\"twitter:site\" content=\"@SmartTan\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"smarttannews\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/news.smarttan.com\/index.php\/further-evidence-that-vitamin-d-might-protect-against-severe-covid-19-disease-and-death\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/news.smarttan.com\/index.php\/further-evidence-that-vitamin-d-might-protect-against-severe-covid-19-disease-and-death\/\"},\"author\":{\"name\":\"smarttannews\",\"@id\":\"https:\/\/news.smarttan.com\/#\/schema\/person\/722dc7049af55e0ed743d67ce9ed4819\"},\"headline\":\"Further evidence that vitamin D might protect against severe COVID-19 disease and death\",\"datePublished\":\"2021-09-27T15:59:23+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/news.smarttan.com\/index.php\/further-evidence-that-vitamin-d-might-protect-against-severe-covid-19-disease-and-death\/\"},\"wordCount\":720,\"publisher\":{\"@id\":\"https:\/\/news.smarttan.com\/#organization\"},\"image\":{\"@id\":\"https:\/\/news.smarttan.com\/index.php\/further-evidence-that-vitamin-d-might-protect-against-severe-covid-19-disease-and-death\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/news.smarttan.com\/wp-content\/uploads\/2021\/09\/Covid-sun-9-27-21.jpg\",\"articleSection\":[\"News\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/news.smarttan.com\/index.php\/further-evidence-that-vitamin-d-might-protect-against-severe-covid-19-disease-and-death\/\",\"url\":\"https:\/\/news.smarttan.com\/index.php\/further-evidence-that-vitamin-d-might-protect-against-severe-covid-19-disease-and-death\/\",\"name\":\"Further evidence that vitamin D might protect against severe COVID-19 disease and death - Smart Tan News\",\"isPartOf\":{\"@id\":\"https:\/\/news.smarttan.com\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/news.smarttan.com\/index.php\/further-evidence-that-vitamin-d-might-protect-against-severe-covid-19-disease-and-death\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/news.smarttan.com\/index.php\/further-evidence-that-vitamin-d-might-protect-against-severe-covid-19-disease-and-death\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/news.smarttan.com\/wp-content\/uploads\/2021\/09\/Covid-sun-9-27-21.jpg\",\"datePublished\":\"2021-09-27T15:59:23+00:00\",\"description\":\"NEWS RELEASE\u00a015-SEP-2021 New research from Trinity College Dublin and University of Edinburgh has examined the association between vitamin D and COVID-19, and found that ambient ultraviolet B (UVB) radiation (which is key for vitamin D production in the skin) at an individual\u2019s place of residence in the weeks before COVID-19 infection, was strongly protective against severe disease and death. 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Few earlier studies attempted this but failed to show a causal link. This could be because UVB radiation sunshine which is the most important source of vitamin D for majority of people was ignored. Researchers, for the first time, looked jointly at genetically-predicted and UVB-predicted vitamin D level. Almost half a million individuals in the UK took part in the study, and ambient UVB radiation before COVID-19 infection was individually assessed for each participant. When comparing the two variables, researchers found that correlation with measured vitamin D concentration in the circulation was three-fold stronger for UVB-predicted vitamin D level, compared to genetically-predicted. Researchers found\u00a0that ambient UVB radiation at an individual\u2019s place of residence preceding COVID-19 infection was strongly and inversely associated with hospitalisation and death.\u00a0This suggests that vitamin D may protect against severe COVID-19 disease and death. Additionally, while the results from the Mendelian Randomisation analysis weren\u2019t conclusive, some indication of a potential causal effect was noted. Because of the relatively weak link between genetically-predicted vitamin D level that is used for Mendelian Randomisation analysis, it is possible that the number of cases in the current study was too small to convincingly determine causal effect, but future larger studies might provide the answer. Professor Lina Zgaga,\u00a0Associate Professor in Epidemiology,\u00a0School of Medicine, Trinity College and senior researcher on the study\u00a0said: \u201cOur study adds further evidence that vitamin D might protect against severe COVID-19 infection. Conducting a properly designed COVID-19 randomised controlled trial of vitamin D supplementation is critical. 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This information is not intended to be used by any party to make unwarranted health claims to promote sunbed usage. Indoor tanning businesses are obligated to communicate a fair and balanced message to all clients about your products and services including the potential risks associated with indoor tanning. Contact your Smart Tan representative to find out more about what you can and can't say in your tanning salon business. \u00a9 2021 International Smart Tan Network. 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The paper has been published in the journal\u00a0Scientific Reports\u00a0today\u00a0(Wednesday, 15th\u00a0September 2021). Previous studies have linked vitamin D deficiency with an increased susceptibility to viral and bacterial respiratory infections. Similarly, several observational studies found a strong correlation between vitamin D deficiency and COVID-19, but it could be that these effects are confounded and in fact a result of other factors, such as obesity, older age or chronic illness which are also linked with low vitamin D. To overcome this, researchers were able to calculate \u201cgenetically-predicted\u201d vitamin D level, that is not confounded by other demographic, health and lifestyle factors, by using the information from over one hundred genes that determine vitamin D status. The Mendelian Randomisation is a particular analytical approach that enabled researchers to investigate whether vitamin D and COVID-19 might be causally linked using genetic data. Few earlier studies attempted this but failed to show a causal link. This could be because UVB radiation sunshine which is the most important source of vitamin D for majority of people was ignored. Researchers, for the first time, looked jointly at genetically-predicted and UVB-predicted vitamin D level. Almost half a million individuals in the UK took part in the study, and ambient UVB radiation before COVID-19 infection was individually assessed for each participant. When comparing the two variables, researchers found that correlation with measured vitamin D concentration in the circulation was three-fold stronger for UVB-predicted vitamin D level, compared to genetically-predicted. Researchers found\u00a0that ambient UVB radiation at an individual\u2019s place of residence preceding COVID-19 infection was strongly and inversely associated with hospitalisation and death.\u00a0This suggests that vitamin D may protect against severe COVID-19 disease and death. Additionally, while the results from the Mendelian Randomisation analysis weren\u2019t conclusive, some indication of a potential causal effect was noted. Because of the relatively weak link between genetically-predicted vitamin D level that is used for Mendelian Randomisation analysis, it is possible that the number of cases in the current study was too small to convincingly determine causal effect, but future larger studies might provide the answer. Professor Lina Zgaga,\u00a0Associate Professor in Epidemiology,\u00a0School of Medicine, Trinity College and senior researcher on the study\u00a0said: \u201cOur study adds further evidence that vitamin D might protect against severe COVID-19 infection. Conducting a properly designed COVID-19 randomised controlled trial of vitamin D supplementation is critical. Until then, given that vitamin D supplements are safe and cheap, it is definitely advisable to take supplements and protect against vitamin D deficiency, particularly with winter on the horizon.\u201d Professor Evropi Theodoratou, Professor of Cancer Epidemiology and Global Health, University of Edinburgh and\u00a0senior researcher on the study\u00a0said: \u201cGiven the lack of highly effective therapies against COVID-19, we think it is important to remain open-minded to emerging results from rigorously conducted studies of vitamin D.\u201d Dr Xue Li, a researcher on the study from Zhejiang University\u00a0said: \u201cOur study supports the recommendation of vitamin D supplementation for not only the maintenance of bone and muscle health during the lock down, but also the potential benefits in relation to protection from COVID-19.\u201d The full paper:\u00a0An observational and Mendelian randomisation study on vitamin D and COVID-19 risk in UK Biobank\u00a0can be read here:\u00a0https:\/\/www.nature.com\/articles\/s41598-021-97679-5   SmartTan.com news articles regularly report medical and scientific information to keep you abreast of current events related to UV light. This information is not intended to be used by any party to make unwarranted health claims to promote sunbed usage. Indoor tanning businesses are obligated to communicate a fair and balanced message to all clients about your products and services including the potential risks associated with indoor tanning. Contact your Smart Tan representative to find out more about what you can and can't say in your tanning salon business. \u00a9 2021 International Smart Tan Network. All rights reserved.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/news.smarttan.com\/index.php\/further-evidence-that-vitamin-d-might-protect-against-severe-covid-19-disease-and-death\/","og_locale":"en_US","og_type":"article","og_title":"Further evidence that vitamin D might protect against severe COVID-19 disease and death - Smart Tan News","og_description":"NEWS RELEASE\u00a015-SEP-2021 New research from Trinity College Dublin and University of Edinburgh has examined the association between vitamin D and COVID-19, and found that ambient ultraviolet B (UVB) radiation (which is key for vitamin D production in the skin) at an individual\u2019s place of residence in the weeks before COVID-19 infection, was strongly protective against severe disease and death. The paper has been published in the journal\u00a0Scientific Reports\u00a0today\u00a0(Wednesday, 15th\u00a0September 2021). Previous studies have linked vitamin D deficiency with an increased susceptibility to viral and bacterial respiratory infections. Similarly, several observational studies found a strong correlation between vitamin D deficiency and COVID-19, but it could be that these effects are confounded and in fact a result of other factors, such as obesity, older age or chronic illness which are also linked with low vitamin D. To overcome this, researchers were able to calculate \u201cgenetically-predicted\u201d vitamin D level, that is not confounded by other demographic, health and lifestyle factors, by using the information from over one hundred genes that determine vitamin D status. The Mendelian Randomisation is a particular analytical approach that enabled researchers to investigate whether vitamin D and COVID-19 might be causally linked using genetic data. Few earlier studies attempted this but failed to show a causal link. This could be because UVB radiation sunshine which is the most important source of vitamin D for majority of people was ignored. Researchers, for the first time, looked jointly at genetically-predicted and UVB-predicted vitamin D level. Almost half a million individuals in the UK took part in the study, and ambient UVB radiation before COVID-19 infection was individually assessed for each participant. When comparing the two variables, researchers found that correlation with measured vitamin D concentration in the circulation was three-fold stronger for UVB-predicted vitamin D level, compared to genetically-predicted. Researchers found\u00a0that ambient UVB radiation at an individual\u2019s place of residence preceding COVID-19 infection was strongly and inversely associated with hospitalisation and death.\u00a0This suggests that vitamin D may protect against severe COVID-19 disease and death. Additionally, while the results from the Mendelian Randomisation analysis weren\u2019t conclusive, some indication of a potential causal effect was noted. Because of the relatively weak link between genetically-predicted vitamin D level that is used for Mendelian Randomisation analysis, it is possible that the number of cases in the current study was too small to convincingly determine causal effect, but future larger studies might provide the answer. Professor Lina Zgaga,\u00a0Associate Professor in Epidemiology,\u00a0School of Medicine, Trinity College and senior researcher on the study\u00a0said: \u201cOur study adds further evidence that vitamin D might protect against severe COVID-19 infection. Conducting a properly designed COVID-19 randomised controlled trial of vitamin D supplementation is critical. Until then, given that vitamin D supplements are safe and cheap, it is definitely advisable to take supplements and protect against vitamin D deficiency, particularly with winter on the horizon.\u201d Professor Evropi Theodoratou, Professor of Cancer Epidemiology and Global Health, University of Edinburgh and\u00a0senior researcher on the study\u00a0said: \u201cGiven the lack of highly effective therapies against COVID-19, we think it is important to remain open-minded to emerging results from rigorously conducted studies of vitamin D.\u201d Dr Xue Li, a researcher on the study from Zhejiang University\u00a0said: \u201cOur study supports the recommendation of vitamin D supplementation for not only the maintenance of bone and muscle health during the lock down, but also the potential benefits in relation to protection from COVID-19.\u201d The full paper:\u00a0An observational and Mendelian randomisation study on vitamin D and COVID-19 risk in UK Biobank\u00a0can be read here:\u00a0https:\/\/www.nature.com\/articles\/s41598-021-97679-5   SmartTan.com news articles regularly report medical and scientific information to keep you abreast of current events related to UV light. This information is not intended to be used by any party to make unwarranted health claims to promote sunbed usage. Indoor tanning businesses are obligated to communicate a fair and balanced message to all clients about your products and services including the potential risks associated with indoor tanning. Contact your Smart Tan representative to find out more about what you can and can't say in your tanning salon business. \u00a9 2021 International Smart Tan Network. All rights reserved.","og_url":"https:\/\/news.smarttan.com\/index.php\/further-evidence-that-vitamin-d-might-protect-against-severe-covid-19-disease-and-death\/","og_site_name":"Smart Tan News","article_publisher":"https:\/\/www.facebook.com\/SmartTan","article_published_time":"2021-09-27T15:59:23+00:00","og_image":[{"width":1360,"height":1000,"url":"https:\/\/news.smarttan.com\/wp-content\/uploads\/2021\/09\/Covid-sun-9-27-21.jpg","type":"image\/jpeg"}],"author":"smarttannews","twitter_card":"summary_large_image","twitter_creator":"@SmartTan","twitter_site":"@SmartTan","twitter_misc":{"Written by":"smarttannews","Est. reading time":"4 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/news.smarttan.com\/index.php\/further-evidence-that-vitamin-d-might-protect-against-severe-covid-19-disease-and-death\/#article","isPartOf":{"@id":"https:\/\/news.smarttan.com\/index.php\/further-evidence-that-vitamin-d-might-protect-against-severe-covid-19-disease-and-death\/"},"author":{"name":"smarttannews","@id":"https:\/\/news.smarttan.com\/#\/schema\/person\/722dc7049af55e0ed743d67ce9ed4819"},"headline":"Further evidence that vitamin D might protect against severe COVID-19 disease and death","datePublished":"2021-09-27T15:59:23+00:00","mainEntityOfPage":{"@id":"https:\/\/news.smarttan.com\/index.php\/further-evidence-that-vitamin-d-might-protect-against-severe-covid-19-disease-and-death\/"},"wordCount":720,"publisher":{"@id":"https:\/\/news.smarttan.com\/#organization"},"image":{"@id":"https:\/\/news.smarttan.com\/index.php\/further-evidence-that-vitamin-d-might-protect-against-severe-covid-19-disease-and-death\/#primaryimage"},"thumbnailUrl":"https:\/\/news.smarttan.com\/wp-content\/uploads\/2021\/09\/Covid-sun-9-27-21.jpg","articleSection":["News"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/news.smarttan.com\/index.php\/further-evidence-that-vitamin-d-might-protect-against-severe-covid-19-disease-and-death\/","url":"https:\/\/news.smarttan.com\/index.php\/further-evidence-that-vitamin-d-might-protect-against-severe-covid-19-disease-and-death\/","name":"Further evidence that vitamin D might protect against severe COVID-19 disease and death - Smart Tan News","isPartOf":{"@id":"https:\/\/news.smarttan.com\/#website"},"primaryImageOfPage":{"@id":"https:\/\/news.smarttan.com\/index.php\/further-evidence-that-vitamin-d-might-protect-against-severe-covid-19-disease-and-death\/#primaryimage"},"image":{"@id":"https:\/\/news.smarttan.com\/index.php\/further-evidence-that-vitamin-d-might-protect-against-severe-covid-19-disease-and-death\/#primaryimage"},"thumbnailUrl":"https:\/\/news.smarttan.com\/wp-content\/uploads\/2021\/09\/Covid-sun-9-27-21.jpg","datePublished":"2021-09-27T15:59:23+00:00","description":"NEWS RELEASE\u00a015-SEP-2021 New research from Trinity College Dublin and University of Edinburgh has examined the association between vitamin D and COVID-19, and found that ambient ultraviolet B (UVB) radiation (which is key for vitamin D production in the skin) at an individual\u2019s place of residence in the weeks before COVID-19 infection, was strongly protective against severe disease and death. The paper has been published in the journal\u00a0Scientific Reports\u00a0today\u00a0(Wednesday, 15th\u00a0September 2021). Previous studies have linked vitamin D deficiency with an increased susceptibility to viral and bacterial respiratory infections. Similarly, several observational studies found a strong correlation between vitamin D deficiency and COVID-19, but it could be that these effects are confounded and in fact a result of other factors, such as obesity, older age or chronic illness which are also linked with low vitamin D. To overcome this, researchers were able to calculate \u201cgenetically-predicted\u201d vitamin D level, that is not confounded by other demographic, health and lifestyle factors, by using the information from over one hundred genes that determine vitamin D status. The Mendelian Randomisation is a particular analytical approach that enabled researchers to investigate whether vitamin D and COVID-19 might be causally linked using genetic data. Few earlier studies attempted this but failed to show a causal link. This could be because UVB radiation sunshine which is the most important source of vitamin D for majority of people was ignored. Researchers, for the first time, looked jointly at genetically-predicted and UVB-predicted vitamin D level. Almost half a million individuals in the UK took part in the study, and ambient UVB radiation before COVID-19 infection was individually assessed for each participant. When comparing the two variables, researchers found that correlation with measured vitamin D concentration in the circulation was three-fold stronger for UVB-predicted vitamin D level, compared to genetically-predicted. Researchers found\u00a0that ambient UVB radiation at an individual\u2019s place of residence preceding COVID-19 infection was strongly and inversely associated with hospitalisation and death.\u00a0This suggests that vitamin D may protect against severe COVID-19 disease and death. Additionally, while the results from the Mendelian Randomisation analysis weren\u2019t conclusive, some indication of a potential causal effect was noted. Because of the relatively weak link between genetically-predicted vitamin D level that is used for Mendelian Randomisation analysis, it is possible that the number of cases in the current study was too small to convincingly determine causal effect, but future larger studies might provide the answer. Professor Lina Zgaga,\u00a0Associate Professor in Epidemiology,\u00a0School of Medicine, Trinity College and senior researcher on the study\u00a0said: \u201cOur study adds further evidence that vitamin D might protect against severe COVID-19 infection. Conducting a properly designed COVID-19 randomised controlled trial of vitamin D supplementation is critical. Until then, given that vitamin D supplements are safe and cheap, it is definitely advisable to take supplements and protect against vitamin D deficiency, particularly with winter on the horizon.\u201d Professor Evropi Theodoratou, Professor of Cancer Epidemiology and Global Health, University of Edinburgh and\u00a0senior researcher on the study\u00a0said: \u201cGiven the lack of highly effective therapies against COVID-19, we think it is important to remain open-minded to emerging results from rigorously conducted studies of vitamin D.\u201d Dr Xue Li, a researcher on the study from Zhejiang University\u00a0said: \u201cOur study supports the recommendation of vitamin D supplementation for not only the maintenance of bone and muscle health during the lock down, but also the potential benefits in relation to protection from COVID-19.\u201d The full paper:\u00a0An observational and Mendelian randomisation study on vitamin D and COVID-19 risk in UK Biobank\u00a0can be read here:\u00a0https:\/\/www.nature.com\/articles\/s41598-021-97679-5   SmartTan.com news articles regularly report medical and scientific information to keep you abreast of current events related to UV light. This information is not intended to be used by any party to make unwarranted health claims to promote sunbed usage. Indoor tanning businesses are obligated to communicate a fair and balanced message to all clients about your products and services including the potential risks associated with indoor tanning. Contact your Smart Tan representative to find out more about what you can and can't say in your tanning salon business. \u00a9 2021 International Smart Tan Network. 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