![\"2009-12-02-d-for-heart-health-tanningnews-copy.jpg\"](\"https:\/\/smarttan.com\/blog\/wp-content\/uploads\/2009\/12\/2009-12-02-d-for-heart-health-tanningnews-copy.jpg\")
<\/a>\u201cThis study is the first indication of a genetic link between vitamin D action and heart disease,\u201d says Robert U. Simpson, professor of pharmacology at the University of Michigan Medical School and one of the authors of the study in the journal Pharmacogenomics<\/em>.<\/p>\n\u201cThis study revealed that a critical enzyme absolutely required for production of the vitamin D hormone has a genetic variant associated with the development of congestive heart failure,\u201d Simpson says. \u201cIf subsequent studies confirm this finding and demonstrate a mechanism, this means that in the future, we may be able to screen earlier for those most vulnerable and slow the progress of the disease.\u201d Such a screening test would be years away.<\/p>\n
Study co-authors Russel A. Wilke of the Medical College of Wisconsin and Catherine A. McCarthy of the Marshfield Clinic Research Foundation in Marshfield, Wis., analyzed the genetic profiles of 617 subjects from the Marshfield Clinic Personalized Medicine Project, a large DNA biobank. They looked for variants in five candidate genes chosen for their roles in vitamin D regulation and hypertension. One-third of the subjects had both hypertension and congestive heart failure, one-third had hypertension alone and one-third were included as healthy controls.<\/p>\n
The results showed that a variant in the CYP27B1 gene was associated with congestive heart failure in patients with hypertension. It is already known that mutations that inactivate this gene reduce the required conversion of vitamin D into an active hormone.<\/p>\n
\u201cThis initial study needs to be confirmed with a larger study that would permit analysis of the full cardiovascular profile of the population possessing the gene variant,\u201d Simpson says. A future study also would need to include people of more diverse origins than this study\u2019s population of mostly European ancestry, the authors say.<\/p>\n
Citation: Pharmacogenomics<\/em>, (2009) 10(11):1789-97<\/strong><\/h6>\nAdditional authors: Bikol N. Mukesh, Satya V. Bhupathi, Richard A. Dart and Nader R. Ghebranious, Center for Human Genetics, Marshfield Clinic Research Foundation<\/strong><\/h6>\nFunding: National Institutes of Health, Marshfield Clinic Personalized Medicine Research Project, Michigan Institute for Clinical and Health Research<\/strong><\/h6>\nPatents\/conflict disclosures: The research was funded in part by donors to cardiology research at Marshfield Clinic. Robert Simpson has a financial interest in and is president of Cardiavent, Inc., a company that is developing an analog (CARDO24) of vitamin D to treat cardiovascular diseases.<\/strong><\/h6>\n","protected":false},"excerpt":{"rendered":"DEC. 2, 2009 (UNIVERSITY OF MICHIGAN PRESS RELEASE) \u2014 Previous studies have shown a link between low vitamin D status and heart disease. Now a new study shows that patients with high blood pressure who possess a gene variant that affects an enzyme critical to normal vitamin D activation are twice as likely as those […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-2750","post","type-post","status-publish","format-standard","hentry","category-news"],"yoast_head":"\n
Another study shows that vitamin D reduces the risk of heart failure - Smart Tan News<\/title>\n<meta name=\"description\" content=\"DEC. 2, 2009 (UNIVERSITY OF MICHIGAN PRESS RELEASE) \u2014 Previous studies have shown a link between low vitamin D status and heart disease. Now a new study shows that patients with high blood pressure who possess a gene variant that affects an enzyme critical to normal vitamin D activation are twice as likely as those without the variant to have congestive heart failure. \u201cThis study is the first indication of a genetic link between vitamin D action and heart disease,\u201d says Robert U. Simpson, professor of pharmacology at the University of Michigan Medical School and one of the authors of the study in the journal Pharmacogenomics. \u201cThis study revealed that a critical enzyme absolutely required for production of the vitamin D hormone has a genetic variant associated with the development of congestive heart failure,\u201d Simpson says. \u201cIf subsequent studies confirm this finding and demonstrate a mechanism, this means that in the future, we may be able to screen earlier for those most vulnerable and slow the progress of the disease.\u201d Such a screening test would be years away. Study co-authors Russel A. Wilke of the Medical College of Wisconsin and Catherine A. McCarthy of the Marshfield Clinic Research Foundation in Marshfield, Wis., analyzed the genetic profiles of 617 subjects from the Marshfield Clinic Personalized Medicine Project, a large DNA biobank. They looked for variants in five candidate genes chosen for their roles in vitamin D regulation and hypertension. One-third of the subjects had both hypertension and congestive heart failure, one-third had hypertension alone and one-third were included as healthy controls. The results showed that a variant in the CYP27B1 gene was associated with congestive heart failure in patients with hypertension. It is already known that mutations that inactivate this gene reduce the required conversion of vitamin D into an active hormone. \u201cThis initial study needs to be confirmed with a larger study that would permit analysis of the full cardiovascular profile of the population possessing the gene variant,\u201d Simpson says. A future study also would need to include people of more diverse origins than this study\u2019s population of mostly European ancestry, the authors say. Citation: Pharmacogenomics, (2009) 10(11):1789-97 Additional authors: Bikol N. Mukesh, Satya V. Bhupathi, Richard A. Dart and Nader R. Ghebranious, Center for Human Genetics, Marshfield Clinic Research Foundation Funding: National Institutes of Health, Marshfield Clinic Personalized Medicine Research Project, Michigan Institute for Clinical and Health Research Patents\/conflict disclosures: The research was funded in part by donors to cardiology research at Marshfield Clinic. Robert Simpson has a financial interest in and is president of Cardiavent, Inc., a company that is developing an analog (CARDO24) of vitamin D to treat cardiovascular diseases.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/news.smarttan.com\/index.php\/another-study-shows-that-vitamin-d-reduces-the-risk-of-heart-failure\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Another study shows that vitamin D reduces the risk of heart failure - Smart Tan News\" \/>\n<meta property=\"og:description\" content=\"DEC. 2, 2009 (UNIVERSITY OF MICHIGAN PRESS RELEASE) \u2014 Previous studies have shown a link between low vitamin D status and heart disease. Now a new study shows that patients with high blood pressure who possess a gene variant that affects an enzyme critical to normal vitamin D activation are twice as likely as those without the variant to have congestive heart failure. \u201cThis study is the first indication of a genetic link between vitamin D action and heart disease,\u201d says Robert U. Simpson, professor of pharmacology at the University of Michigan Medical School and one of the authors of the study in the journal Pharmacogenomics. \u201cThis study revealed that a critical enzyme absolutely required for production of the vitamin D hormone has a genetic variant associated with the development of congestive heart failure,\u201d Simpson says. \u201cIf subsequent studies confirm this finding and demonstrate a mechanism, this means that in the future, we may be able to screen earlier for those most vulnerable and slow the progress of the disease.\u201d Such a screening test would be years away. Study co-authors Russel A. Wilke of the Medical College of Wisconsin and Catherine A. McCarthy of the Marshfield Clinic Research Foundation in Marshfield, Wis., analyzed the genetic profiles of 617 subjects from the Marshfield Clinic Personalized Medicine Project, a large DNA biobank. They looked for variants in five candidate genes chosen for their roles in vitamin D regulation and hypertension. One-third of the subjects had both hypertension and congestive heart failure, one-third had hypertension alone and one-third were included as healthy controls. The results showed that a variant in the CYP27B1 gene was associated with congestive heart failure in patients with hypertension. It is already known that mutations that inactivate this gene reduce the required conversion of vitamin D into an active hormone. \u201cThis initial study needs to be confirmed with a larger study that would permit analysis of the full cardiovascular profile of the population possessing the gene variant,\u201d Simpson says. A future study also would need to include people of more diverse origins than this study\u2019s population of mostly European ancestry, the authors say. Citation: Pharmacogenomics, (2009) 10(11):1789-97 Additional authors: Bikol N. Mukesh, Satya V. Bhupathi, Richard A. Dart and Nader R. Ghebranious, Center for Human Genetics, Marshfield Clinic Research Foundation Funding: National Institutes of Health, Marshfield Clinic Personalized Medicine Research Project, Michigan Institute for Clinical and Health Research Patents\/conflict disclosures: The research was funded in part by donors to cardiology research at Marshfield Clinic. Robert Simpson has a financial interest in and is president of Cardiavent, Inc., a company that is developing an analog (CARDO24) of vitamin D to treat cardiovascular diseases.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/news.smarttan.com\/index.php\/another-study-shows-that-vitamin-d-reduces-the-risk-of-heart-failure\/\" \/>\n<meta property=\"og:site_name\" content=\"Smart Tan News\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/SmartTan\" \/>\n<meta property=\"article:published_time\" content=\"2009-12-03T07:59:26+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2011-10-31T16:23:47+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/smarttan.com\/blog\/wp-content\/uploads\/2009\/12\/2009-12-02-d-for-heart-health-tanningnews-copy.thumbnail.jpg\" \/>\n<meta name=\"author\" content=\"smarttan\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@SmartTan\" \/>\n<meta name=\"twitter:site\" content=\"@SmartTan\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"smarttan\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/news.smarttan.com\/index.php\/another-study-shows-that-vitamin-d-reduces-the-risk-of-heart-failure\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/news.smarttan.com\/index.php\/another-study-shows-that-vitamin-d-reduces-the-risk-of-heart-failure\/\"},\"author\":{\"name\":\"smarttan\",\"@id\":\"https:\/\/news.smarttan.com\/#\/schema\/person\/4191f4b1131c0a37b4fd39f876771e7b\"},\"headline\":\"Another study shows that vitamin D reduces the risk of heart failure\",\"datePublished\":\"2009-12-03T07:59:26+00:00\",\"dateModified\":\"2011-10-31T16:23:47+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/news.smarttan.com\/index.php\/another-study-shows-that-vitamin-d-reduces-the-risk-of-heart-failure\/\"},\"wordCount\":453,\"publisher\":{\"@id\":\"https:\/\/news.smarttan.com\/#organization\"},\"image\":{\"@id\":\"https:\/\/news.smarttan.com\/index.php\/another-study-shows-that-vitamin-d-reduces-the-risk-of-heart-failure\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/smarttan.com\/blog\/wp-content\/uploads\/2009\/12\/2009-12-02-d-for-heart-health-tanningnews-copy.thumbnail.jpg\",\"articleSection\":[\"News\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/news.smarttan.com\/index.php\/another-study-shows-that-vitamin-d-reduces-the-risk-of-heart-failure\/\",\"url\":\"https:\/\/news.smarttan.com\/index.php\/another-study-shows-that-vitamin-d-reduces-the-risk-of-heart-failure\/\",\"name\":\"Another study shows that vitamin D reduces the risk of heart failure - Smart Tan News\",\"isPartOf\":{\"@id\":\"https:\/\/news.smarttan.com\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/news.smarttan.com\/index.php\/another-study-shows-that-vitamin-d-reduces-the-risk-of-heart-failure\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/news.smarttan.com\/index.php\/another-study-shows-that-vitamin-d-reduces-the-risk-of-heart-failure\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/smarttan.com\/blog\/wp-content\/uploads\/2009\/12\/2009-12-02-d-for-heart-health-tanningnews-copy.thumbnail.jpg\",\"datePublished\":\"2009-12-03T07:59:26+00:00\",\"dateModified\":\"2011-10-31T16:23:47+00:00\",\"description\":\"DEC. 2, 2009 (UNIVERSITY OF MICHIGAN PRESS RELEASE) \u2014 Previous studies have shown a link between low vitamin D status and heart disease. Now a new study shows that patients with high blood pressure who possess a gene variant that affects an enzyme critical to normal vitamin D activation are twice as likely as those without the variant to have congestive heart failure. \u201cThis study is the first indication of a genetic link between vitamin D action and heart disease,\u201d says Robert U. Simpson, professor of pharmacology at the University of Michigan Medical School and one of the authors of the study in the journal Pharmacogenomics. \u201cThis study revealed that a critical enzyme absolutely required for production of the vitamin D hormone has a genetic variant associated with the development of congestive heart failure,\u201d Simpson says. \u201cIf subsequent studies confirm this finding and demonstrate a mechanism, this means that in the future, we may be able to screen earlier for those most vulnerable and slow the progress of the disease.\u201d Such a screening test would be years away. Study co-authors Russel A. Wilke of the Medical College of Wisconsin and Catherine A. McCarthy of the Marshfield Clinic Research Foundation in Marshfield, Wis., analyzed the genetic profiles of 617 subjects from the Marshfield Clinic Personalized Medicine Project, a large DNA biobank. They looked for variants in five candidate genes chosen for their roles in vitamin D regulation and hypertension. One-third of the subjects had both hypertension and congestive heart failure, one-third had hypertension alone and one-third were included as healthy controls. The results showed that a variant in the CYP27B1 gene was associated with congestive heart failure in patients with hypertension. It is already known that mutations that inactivate this gene reduce the required conversion of vitamin D into an active hormone. \u201cThis initial study needs to be confirmed with a larger study that would permit analysis of the full cardiovascular profile of the population possessing the gene variant,\u201d Simpson says. A future study also would need to include people of more diverse origins than this study\u2019s population of mostly European ancestry, the authors say. Citation: Pharmacogenomics, (2009) 10(11):1789-97 Additional authors: Bikol N. Mukesh, Satya V. Bhupathi, Richard A. Dart and Nader R. Ghebranious, Center for Human Genetics, Marshfield Clinic Research Foundation Funding: National Institutes of Health, Marshfield Clinic Personalized Medicine Research Project, Michigan Institute for Clinical and Health Research Patents\/conflict disclosures: The research was funded in part by donors to cardiology research at Marshfield Clinic. 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Now a new study shows that patients with high blood pressure who possess a gene variant that affects an enzyme critical to normal vitamin D activation are twice as likely as those without the variant to have congestive heart failure. \u201cThis study is the first indication of a genetic link between vitamin D action and heart disease,\u201d says Robert U. Simpson, professor of pharmacology at the University of Michigan Medical School and one of the authors of the study in the journal Pharmacogenomics. \u201cThis study revealed that a critical enzyme absolutely required for production of the vitamin D hormone has a genetic variant associated with the development of congestive heart failure,\u201d Simpson says. \u201cIf subsequent studies confirm this finding and demonstrate a mechanism, this means that in the future, we may be able to screen earlier for those most vulnerable and slow the progress of the disease.\u201d Such a screening test would be years away. Study co-authors Russel A. Wilke of the Medical College of Wisconsin and Catherine A. McCarthy of the Marshfield Clinic Research Foundation in Marshfield, Wis., analyzed the genetic profiles of 617 subjects from the Marshfield Clinic Personalized Medicine Project, a large DNA biobank. They looked for variants in five candidate genes chosen for their roles in vitamin D regulation and hypertension. One-third of the subjects had both hypertension and congestive heart failure, one-third had hypertension alone and one-third were included as healthy controls. The results showed that a variant in the CYP27B1 gene was associated with congestive heart failure in patients with hypertension. It is already known that mutations that inactivate this gene reduce the required conversion of vitamin D into an active hormone. \u201cThis initial study needs to be confirmed with a larger study that would permit analysis of the full cardiovascular profile of the population possessing the gene variant,\u201d Simpson says. A future study also would need to include people of more diverse origins than this study\u2019s population of mostly European ancestry, the authors say. Citation: Pharmacogenomics, (2009) 10(11):1789-97 Additional authors: Bikol N. Mukesh, Satya V. Bhupathi, Richard A. Dart and Nader R. Ghebranious, Center for Human Genetics, Marshfield Clinic Research Foundation Funding: National Institutes of Health, Marshfield Clinic Personalized Medicine Research Project, Michigan Institute for Clinical and Health Research Patents\/conflict disclosures: The research was funded in part by donors to cardiology research at Marshfield Clinic. Robert Simpson has a financial interest in and is president of Cardiavent, Inc., a company that is developing an analog (CARDO24) of vitamin D to treat cardiovascular diseases.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/news.smarttan.com\/index.php\/another-study-shows-that-vitamin-d-reduces-the-risk-of-heart-failure\/","og_locale":"en_US","og_type":"article","og_title":"Another study shows that vitamin D reduces the risk of heart failure - Smart Tan News","og_description":"DEC. 2, 2009 (UNIVERSITY OF MICHIGAN PRESS RELEASE) \u2014 Previous studies have shown a link between low vitamin D status and heart disease. Now a new study shows that patients with high blood pressure who possess a gene variant that affects an enzyme critical to normal vitamin D activation are twice as likely as those without the variant to have congestive heart failure. \u201cThis study is the first indication of a genetic link between vitamin D action and heart disease,\u201d says Robert U. Simpson, professor of pharmacology at the University of Michigan Medical School and one of the authors of the study in the journal Pharmacogenomics. \u201cThis study revealed that a critical enzyme absolutely required for production of the vitamin D hormone has a genetic variant associated with the development of congestive heart failure,\u201d Simpson says. \u201cIf subsequent studies confirm this finding and demonstrate a mechanism, this means that in the future, we may be able to screen earlier for those most vulnerable and slow the progress of the disease.\u201d Such a screening test would be years away. Study co-authors Russel A. Wilke of the Medical College of Wisconsin and Catherine A. McCarthy of the Marshfield Clinic Research Foundation in Marshfield, Wis., analyzed the genetic profiles of 617 subjects from the Marshfield Clinic Personalized Medicine Project, a large DNA biobank. They looked for variants in five candidate genes chosen for their roles in vitamin D regulation and hypertension. One-third of the subjects had both hypertension and congestive heart failure, one-third had hypertension alone and one-third were included as healthy controls. The results showed that a variant in the CYP27B1 gene was associated with congestive heart failure in patients with hypertension. It is already known that mutations that inactivate this gene reduce the required conversion of vitamin D into an active hormone. \u201cThis initial study needs to be confirmed with a larger study that would permit analysis of the full cardiovascular profile of the population possessing the gene variant,\u201d Simpson says. A future study also would need to include people of more diverse origins than this study\u2019s population of mostly European ancestry, the authors say. Citation: Pharmacogenomics, (2009) 10(11):1789-97 Additional authors: Bikol N. Mukesh, Satya V. Bhupathi, Richard A. Dart and Nader R. Ghebranious, Center for Human Genetics, Marshfield Clinic Research Foundation Funding: National Institutes of Health, Marshfield Clinic Personalized Medicine Research Project, Michigan Institute for Clinical and Health Research Patents\/conflict disclosures: The research was funded in part by donors to cardiology research at Marshfield Clinic. Robert Simpson has a financial interest in and is president of Cardiavent, Inc., a company that is developing an analog (CARDO24) of vitamin D to treat cardiovascular diseases.","og_url":"https:\/\/news.smarttan.com\/index.php\/another-study-shows-that-vitamin-d-reduces-the-risk-of-heart-failure\/","og_site_name":"Smart Tan News","article_publisher":"https:\/\/www.facebook.com\/SmartTan","article_published_time":"2009-12-03T07:59:26+00:00","article_modified_time":"2011-10-31T16:23:47+00:00","og_image":[{"url":"https:\/\/smarttan.com\/blog\/wp-content\/uploads\/2009\/12\/2009-12-02-d-for-heart-health-tanningnews-copy.thumbnail.jpg","type":"","width":"","height":""}],"author":"smarttan","twitter_card":"summary_large_image","twitter_creator":"@SmartTan","twitter_site":"@SmartTan","twitter_misc":{"Written by":"smarttan","Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/news.smarttan.com\/index.php\/another-study-shows-that-vitamin-d-reduces-the-risk-of-heart-failure\/#article","isPartOf":{"@id":"https:\/\/news.smarttan.com\/index.php\/another-study-shows-that-vitamin-d-reduces-the-risk-of-heart-failure\/"},"author":{"name":"smarttan","@id":"https:\/\/news.smarttan.com\/#\/schema\/person\/4191f4b1131c0a37b4fd39f876771e7b"},"headline":"Another study shows that vitamin D reduces the risk of heart failure","datePublished":"2009-12-03T07:59:26+00:00","dateModified":"2011-10-31T16:23:47+00:00","mainEntityOfPage":{"@id":"https:\/\/news.smarttan.com\/index.php\/another-study-shows-that-vitamin-d-reduces-the-risk-of-heart-failure\/"},"wordCount":453,"publisher":{"@id":"https:\/\/news.smarttan.com\/#organization"},"image":{"@id":"https:\/\/news.smarttan.com\/index.php\/another-study-shows-that-vitamin-d-reduces-the-risk-of-heart-failure\/#primaryimage"},"thumbnailUrl":"https:\/\/smarttan.com\/blog\/wp-content\/uploads\/2009\/12\/2009-12-02-d-for-heart-health-tanningnews-copy.thumbnail.jpg","articleSection":["News"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/news.smarttan.com\/index.php\/another-study-shows-that-vitamin-d-reduces-the-risk-of-heart-failure\/","url":"https:\/\/news.smarttan.com\/index.php\/another-study-shows-that-vitamin-d-reduces-the-risk-of-heart-failure\/","name":"Another study shows that vitamin D reduces the risk of heart failure - Smart Tan News","isPartOf":{"@id":"https:\/\/news.smarttan.com\/#website"},"primaryImageOfPage":{"@id":"https:\/\/news.smarttan.com\/index.php\/another-study-shows-that-vitamin-d-reduces-the-risk-of-heart-failure\/#primaryimage"},"image":{"@id":"https:\/\/news.smarttan.com\/index.php\/another-study-shows-that-vitamin-d-reduces-the-risk-of-heart-failure\/#primaryimage"},"thumbnailUrl":"https:\/\/smarttan.com\/blog\/wp-content\/uploads\/2009\/12\/2009-12-02-d-for-heart-health-tanningnews-copy.thumbnail.jpg","datePublished":"2009-12-03T07:59:26+00:00","dateModified":"2011-10-31T16:23:47+00:00","description":"DEC. 2, 2009 (UNIVERSITY OF MICHIGAN PRESS RELEASE) \u2014 Previous studies have shown a link between low vitamin D status and heart disease. Now a new study shows that patients with high blood pressure who possess a gene variant that affects an enzyme critical to normal vitamin D activation are twice as likely as those without the variant to have congestive heart failure. \u201cThis study is the first indication of a genetic link between vitamin D action and heart disease,\u201d says Robert U. Simpson, professor of pharmacology at the University of Michigan Medical School and one of the authors of the study in the journal Pharmacogenomics. \u201cThis study revealed that a critical enzyme absolutely required for production of the vitamin D hormone has a genetic variant associated with the development of congestive heart failure,\u201d Simpson says. \u201cIf subsequent studies confirm this finding and demonstrate a mechanism, this means that in the future, we may be able to screen earlier for those most vulnerable and slow the progress of the disease.\u201d Such a screening test would be years away. Study co-authors Russel A. Wilke of the Medical College of Wisconsin and Catherine A. McCarthy of the Marshfield Clinic Research Foundation in Marshfield, Wis., analyzed the genetic profiles of 617 subjects from the Marshfield Clinic Personalized Medicine Project, a large DNA biobank. They looked for variants in five candidate genes chosen for their roles in vitamin D regulation and hypertension. One-third of the subjects had both hypertension and congestive heart failure, one-third had hypertension alone and one-third were included as healthy controls. The results showed that a variant in the CYP27B1 gene was associated with congestive heart failure in patients with hypertension. It is already known that mutations that inactivate this gene reduce the required conversion of vitamin D into an active hormone. \u201cThis initial study needs to be confirmed with a larger study that would permit analysis of the full cardiovascular profile of the population possessing the gene variant,\u201d Simpson says. A future study also would need to include people of more diverse origins than this study\u2019s population of mostly European ancestry, the authors say. Citation: Pharmacogenomics, (2009) 10(11):1789-97 Additional authors: Bikol N. Mukesh, Satya V. Bhupathi, Richard A. Dart and Nader R. Ghebranious, Center for Human Genetics, Marshfield Clinic Research Foundation Funding: National Institutes of Health, Marshfield Clinic Personalized Medicine Research Project, Michigan Institute for Clinical and Health Research Patents\/conflict disclosures: The research was funded in part by donors to cardiology research at Marshfield Clinic. Robert Simpson has a financial interest in and is president of Cardiavent, Inc., a company that is developing an analog (CARDO24) of vitamin D to treat cardiovascular diseases.","breadcrumb":{"@id":"https:\/\/news.smarttan.com\/index.php\/another-study-shows-that-vitamin-d-reduces-the-risk-of-heart-failure\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/news.smarttan.com\/index.php\/another-study-shows-that-vitamin-d-reduces-the-risk-of-heart-failure\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/news.smarttan.com\/index.php\/another-study-shows-that-vitamin-d-reduces-the-risk-of-heart-failure\/#primaryimage","url":"https:\/\/smarttan.com\/blog\/wp-content\/uploads\/2009\/12\/2009-12-02-d-for-heart-health-tanningnews-copy.thumbnail.jpg","contentUrl":"https:\/\/smarttan.com\/blog\/wp-content\/uploads\/2009\/12\/2009-12-02-d-for-heart-health-tanningnews-copy.thumbnail.jpg"},{"@type":"BreadcrumbList","@id":"https:\/\/news.smarttan.com\/index.php\/another-study-shows-that-vitamin-d-reduces-the-risk-of-heart-failure\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/news.smarttan.com\/"},{"@type":"ListItem","position":2,"name":"Another study shows that vitamin D reduces the risk of heart failure"}]},{"@type":"WebSite","@id":"https:\/\/news.smarttan.com\/#website","url":"https:\/\/news.smarttan.com\/","name":"Smart Tan News","description":"","publisher":{"@id":"https:\/\/news.smarttan.com\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/news.smarttan.com\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/news.smarttan.com\/#organization","name":"Smart Tan","url":"https:\/\/news.smarttan.com\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/news.smarttan.com\/#\/schema\/logo\/image\/","url":"https:\/\/smarttan.com\/news\/wp-content\/uploads\/2022\/08\/Smart-Tan.png","contentUrl":"https:\/\/smarttan.com\/news\/wp-content\/uploads\/2022\/08\/Smart-Tan.png","width":500,"height":164,"caption":"Smart Tan"},"image":{"@id":"https:\/\/news.smarttan.com\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/SmartTan","https:\/\/x.com\/SmartTan"]},{"@type":"Person","@id":"https:\/\/news.smarttan.com\/#\/schema\/person\/4191f4b1131c0a37b4fd39f876771e7b","name":"smarttan","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/60bebff64d4c62315967b9126de927b81d5a9d9511fd52f9dbe9e8b344149182?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/60bebff64d4c62315967b9126de927b81d5a9d9511fd52f9dbe9e8b344149182?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/60bebff64d4c62315967b9126de927b81d5a9d9511fd52f9dbe9e8b344149182?s=96&d=mm&r=g","caption":"smarttan"},"url":"https:\/\/news.smarttan.com\/index.php\/author\/smarttan\/"}]}},"_links":{"self":[{"href":"https:\/\/news.smarttan.com\/index.php\/wp-json\/wp\/v2\/posts\/2750","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/news.smarttan.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/news.smarttan.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/news.smarttan.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/news.smarttan.com\/index.php\/wp-json\/wp\/v2\/comments?post=2750"}],"version-history":[{"count":1,"href":"https:\/\/news.smarttan.com\/index.php\/wp-json\/wp\/v2\/posts\/2750\/revisions"}],"predecessor-version":[{"id":6867,"href":"https:\/\/news.smarttan.com\/index.php\/wp-json\/wp\/v2\/posts\/2750\/revisions\/6867"}],"wp:attachment":[{"href":"https:\/\/news.smarttan.com\/index.php\/wp-json\/wp\/v2\/media?parent=2750"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/news.smarttan.com\/index.php\/wp-json\/wp\/v2\/categories?post=2750"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/news.smarttan.com\/index.php\/wp-json\/wp\/v2\/tags?post=2750"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Funding: National Institutes of Health, Marshfield Clinic Personalized Medicine Research Project, Michigan Institute for Clinical and Health Research<\/strong><\/h6>\nPatents\/conflict disclosures: The research was funded in part by donors to cardiology research at Marshfield Clinic. Robert Simpson has a financial interest in and is president of Cardiavent, Inc., a company that is developing an analog (CARDO24) of vitamin D to treat cardiovascular diseases.<\/strong><\/h6>\n","protected":false},"excerpt":{"rendered":"DEC. 2, 2009 (UNIVERSITY OF MICHIGAN PRESS RELEASE) \u2014 Previous studies have shown a link between low vitamin D status and heart disease. Now a new study shows that patients with high blood pressure who possess a gene variant that affects an enzyme critical to normal vitamin D activation are twice as likely as those […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-2750","post","type-post","status-publish","format-standard","hentry","category-news"],"yoast_head":"\n
Another study shows that vitamin D reduces the risk of heart failure - Smart Tan News<\/title>\n<meta name=\"description\" content=\"DEC. 2, 2009 (UNIVERSITY OF MICHIGAN PRESS RELEASE) \u2014 Previous studies have shown a link between low vitamin D status and heart disease. Now a new study shows that patients with high blood pressure who possess a gene variant that affects an enzyme critical to normal vitamin D activation are twice as likely as those without the variant to have congestive heart failure. \u201cThis study is the first indication of a genetic link between vitamin D action and heart disease,\u201d says Robert U. Simpson, professor of pharmacology at the University of Michigan Medical School and one of the authors of the study in the journal Pharmacogenomics. \u201cThis study revealed that a critical enzyme absolutely required for production of the vitamin D hormone has a genetic variant associated with the development of congestive heart failure,\u201d Simpson says. \u201cIf subsequent studies confirm this finding and demonstrate a mechanism, this means that in the future, we may be able to screen earlier for those most vulnerable and slow the progress of the disease.\u201d Such a screening test would be years away. Study co-authors Russel A. Wilke of the Medical College of Wisconsin and Catherine A. McCarthy of the Marshfield Clinic Research Foundation in Marshfield, Wis., analyzed the genetic profiles of 617 subjects from the Marshfield Clinic Personalized Medicine Project, a large DNA biobank. They looked for variants in five candidate genes chosen for their roles in vitamin D regulation and hypertension. One-third of the subjects had both hypertension and congestive heart failure, one-third had hypertension alone and one-third were included as healthy controls. The results showed that a variant in the CYP27B1 gene was associated with congestive heart failure in patients with hypertension. It is already known that mutations that inactivate this gene reduce the required conversion of vitamin D into an active hormone. \u201cThis initial study needs to be confirmed with a larger study that would permit analysis of the full cardiovascular profile of the population possessing the gene variant,\u201d Simpson says. A future study also would need to include people of more diverse origins than this study\u2019s population of mostly European ancestry, the authors say. Citation: Pharmacogenomics, (2009) 10(11):1789-97 Additional authors: Bikol N. Mukesh, Satya V. Bhupathi, Richard A. Dart and Nader R. Ghebranious, Center for Human Genetics, Marshfield Clinic Research Foundation Funding: National Institutes of Health, Marshfield Clinic Personalized Medicine Research Project, Michigan Institute for Clinical and Health Research Patents\/conflict disclosures: The research was funded in part by donors to cardiology research at Marshfield Clinic. Robert Simpson has a financial interest in and is president of Cardiavent, Inc., a company that is developing an analog (CARDO24) of vitamin D to treat cardiovascular diseases.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/news.smarttan.com\/index.php\/another-study-shows-that-vitamin-d-reduces-the-risk-of-heart-failure\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Another study shows that vitamin D reduces the risk of heart failure - Smart Tan News\" \/>\n<meta property=\"og:description\" content=\"DEC. 2, 2009 (UNIVERSITY OF MICHIGAN PRESS RELEASE) \u2014 Previous studies have shown a link between low vitamin D status and heart disease. Now a new study shows that patients with high blood pressure who possess a gene variant that affects an enzyme critical to normal vitamin D activation are twice as likely as those without the variant to have congestive heart failure. \u201cThis study is the first indication of a genetic link between vitamin D action and heart disease,\u201d says Robert U. Simpson, professor of pharmacology at the University of Michigan Medical School and one of the authors of the study in the journal Pharmacogenomics. \u201cThis study revealed that a critical enzyme absolutely required for production of the vitamin D hormone has a genetic variant associated with the development of congestive heart failure,\u201d Simpson says. \u201cIf subsequent studies confirm this finding and demonstrate a mechanism, this means that in the future, we may be able to screen earlier for those most vulnerable and slow the progress of the disease.\u201d Such a screening test would be years away. Study co-authors Russel A. Wilke of the Medical College of Wisconsin and Catherine A. McCarthy of the Marshfield Clinic Research Foundation in Marshfield, Wis., analyzed the genetic profiles of 617 subjects from the Marshfield Clinic Personalized Medicine Project, a large DNA biobank. They looked for variants in five candidate genes chosen for their roles in vitamin D regulation and hypertension. One-third of the subjects had both hypertension and congestive heart failure, one-third had hypertension alone and one-third were included as healthy controls. The results showed that a variant in the CYP27B1 gene was associated with congestive heart failure in patients with hypertension. It is already known that mutations that inactivate this gene reduce the required conversion of vitamin D into an active hormone. \u201cThis initial study needs to be confirmed with a larger study that would permit analysis of the full cardiovascular profile of the population possessing the gene variant,\u201d Simpson says. A future study also would need to include people of more diverse origins than this study\u2019s population of mostly European ancestry, the authors say. Citation: Pharmacogenomics, (2009) 10(11):1789-97 Additional authors: Bikol N. Mukesh, Satya V. Bhupathi, Richard A. Dart and Nader R. Ghebranious, Center for Human Genetics, Marshfield Clinic Research Foundation Funding: National Institutes of Health, Marshfield Clinic Personalized Medicine Research Project, Michigan Institute for Clinical and Health Research Patents\/conflict disclosures: The research was funded in part by donors to cardiology research at Marshfield Clinic. Robert Simpson has a financial interest in and is president of Cardiavent, Inc., a company that is developing an analog (CARDO24) of vitamin D to treat cardiovascular diseases.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/news.smarttan.com\/index.php\/another-study-shows-that-vitamin-d-reduces-the-risk-of-heart-failure\/\" \/>\n<meta property=\"og:site_name\" content=\"Smart Tan News\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/SmartTan\" \/>\n<meta property=\"article:published_time\" content=\"2009-12-03T07:59:26+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2011-10-31T16:23:47+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/smarttan.com\/blog\/wp-content\/uploads\/2009\/12\/2009-12-02-d-for-heart-health-tanningnews-copy.thumbnail.jpg\" \/>\n<meta name=\"author\" content=\"smarttan\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@SmartTan\" \/>\n<meta name=\"twitter:site\" content=\"@SmartTan\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"smarttan\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/news.smarttan.com\/index.php\/another-study-shows-that-vitamin-d-reduces-the-risk-of-heart-failure\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/news.smarttan.com\/index.php\/another-study-shows-that-vitamin-d-reduces-the-risk-of-heart-failure\/\"},\"author\":{\"name\":\"smarttan\",\"@id\":\"https:\/\/news.smarttan.com\/#\/schema\/person\/4191f4b1131c0a37b4fd39f876771e7b\"},\"headline\":\"Another study shows that vitamin D reduces the risk of heart failure\",\"datePublished\":\"2009-12-03T07:59:26+00:00\",\"dateModified\":\"2011-10-31T16:23:47+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/news.smarttan.com\/index.php\/another-study-shows-that-vitamin-d-reduces-the-risk-of-heart-failure\/\"},\"wordCount\":453,\"publisher\":{\"@id\":\"https:\/\/news.smarttan.com\/#organization\"},\"image\":{\"@id\":\"https:\/\/news.smarttan.com\/index.php\/another-study-shows-that-vitamin-d-reduces-the-risk-of-heart-failure\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/smarttan.com\/blog\/wp-content\/uploads\/2009\/12\/2009-12-02-d-for-heart-health-tanningnews-copy.thumbnail.jpg\",\"articleSection\":[\"News\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/news.smarttan.com\/index.php\/another-study-shows-that-vitamin-d-reduces-the-risk-of-heart-failure\/\",\"url\":\"https:\/\/news.smarttan.com\/index.php\/another-study-shows-that-vitamin-d-reduces-the-risk-of-heart-failure\/\",\"name\":\"Another study shows that vitamin D reduces the risk of heart failure - Smart Tan News\",\"isPartOf\":{\"@id\":\"https:\/\/news.smarttan.com\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/news.smarttan.com\/index.php\/another-study-shows-that-vitamin-d-reduces-the-risk-of-heart-failure\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/news.smarttan.com\/index.php\/another-study-shows-that-vitamin-d-reduces-the-risk-of-heart-failure\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/smarttan.com\/blog\/wp-content\/uploads\/2009\/12\/2009-12-02-d-for-heart-health-tanningnews-copy.thumbnail.jpg\",\"datePublished\":\"2009-12-03T07:59:26+00:00\",\"dateModified\":\"2011-10-31T16:23:47+00:00\",\"description\":\"DEC. 2, 2009 (UNIVERSITY OF MICHIGAN PRESS RELEASE) \u2014 Previous studies have shown a link between low vitamin D status and heart disease. Now a new study shows that patients with high blood pressure who possess a gene variant that affects an enzyme critical to normal vitamin D activation are twice as likely as those without the variant to have congestive heart failure. \u201cThis study is the first indication of a genetic link between vitamin D action and heart disease,\u201d says Robert U. Simpson, professor of pharmacology at the University of Michigan Medical School and one of the authors of the study in the journal Pharmacogenomics. \u201cThis study revealed that a critical enzyme absolutely required for production of the vitamin D hormone has a genetic variant associated with the development of congestive heart failure,\u201d Simpson says. \u201cIf subsequent studies confirm this finding and demonstrate a mechanism, this means that in the future, we may be able to screen earlier for those most vulnerable and slow the progress of the disease.\u201d Such a screening test would be years away. Study co-authors Russel A. Wilke of the Medical College of Wisconsin and Catherine A. McCarthy of the Marshfield Clinic Research Foundation in Marshfield, Wis., analyzed the genetic profiles of 617 subjects from the Marshfield Clinic Personalized Medicine Project, a large DNA biobank. They looked for variants in five candidate genes chosen for their roles in vitamin D regulation and hypertension. One-third of the subjects had both hypertension and congestive heart failure, one-third had hypertension alone and one-third were included as healthy controls. The results showed that a variant in the CYP27B1 gene was associated with congestive heart failure in patients with hypertension. It is already known that mutations that inactivate this gene reduce the required conversion of vitamin D into an active hormone. \u201cThis initial study needs to be confirmed with a larger study that would permit analysis of the full cardiovascular profile of the population possessing the gene variant,\u201d Simpson says. A future study also would need to include people of more diverse origins than this study\u2019s population of mostly European ancestry, the authors say. Citation: Pharmacogenomics, (2009) 10(11):1789-97 Additional authors: Bikol N. Mukesh, Satya V. Bhupathi, Richard A. Dart and Nader R. Ghebranious, Center for Human Genetics, Marshfield Clinic Research Foundation Funding: National Institutes of Health, Marshfield Clinic Personalized Medicine Research Project, Michigan Institute for Clinical and Health Research Patents\/conflict disclosures: The research was funded in part by donors to cardiology research at Marshfield Clinic. 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Now a new study shows that patients with high blood pressure who possess a gene variant that affects an enzyme critical to normal vitamin D activation are twice as likely as those without the variant to have congestive heart failure. \u201cThis study is the first indication of a genetic link between vitamin D action and heart disease,\u201d says Robert U. Simpson, professor of pharmacology at the University of Michigan Medical School and one of the authors of the study in the journal Pharmacogenomics. \u201cThis study revealed that a critical enzyme absolutely required for production of the vitamin D hormone has a genetic variant associated with the development of congestive heart failure,\u201d Simpson says. \u201cIf subsequent studies confirm this finding and demonstrate a mechanism, this means that in the future, we may be able to screen earlier for those most vulnerable and slow the progress of the disease.\u201d Such a screening test would be years away. Study co-authors Russel A. Wilke of the Medical College of Wisconsin and Catherine A. McCarthy of the Marshfield Clinic Research Foundation in Marshfield, Wis., analyzed the genetic profiles of 617 subjects from the Marshfield Clinic Personalized Medicine Project, a large DNA biobank. They looked for variants in five candidate genes chosen for their roles in vitamin D regulation and hypertension. One-third of the subjects had both hypertension and congestive heart failure, one-third had hypertension alone and one-third were included as healthy controls. The results showed that a variant in the CYP27B1 gene was associated with congestive heart failure in patients with hypertension. It is already known that mutations that inactivate this gene reduce the required conversion of vitamin D into an active hormone. \u201cThis initial study needs to be confirmed with a larger study that would permit analysis of the full cardiovascular profile of the population possessing the gene variant,\u201d Simpson says. A future study also would need to include people of more diverse origins than this study\u2019s population of mostly European ancestry, the authors say. Citation: Pharmacogenomics, (2009) 10(11):1789-97 Additional authors: Bikol N. Mukesh, Satya V. Bhupathi, Richard A. Dart and Nader R. Ghebranious, Center for Human Genetics, Marshfield Clinic Research Foundation Funding: National Institutes of Health, Marshfield Clinic Personalized Medicine Research Project, Michigan Institute for Clinical and Health Research Patents\/conflict disclosures: The research was funded in part by donors to cardiology research at Marshfield Clinic. Robert Simpson has a financial interest in and is president of Cardiavent, Inc., a company that is developing an analog (CARDO24) of vitamin D to treat cardiovascular diseases.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/news.smarttan.com\/index.php\/another-study-shows-that-vitamin-d-reduces-the-risk-of-heart-failure\/","og_locale":"en_US","og_type":"article","og_title":"Another study shows that vitamin D reduces the risk of heart failure - Smart Tan News","og_description":"DEC. 2, 2009 (UNIVERSITY OF MICHIGAN PRESS RELEASE) \u2014 Previous studies have shown a link between low vitamin D status and heart disease. Now a new study shows that patients with high blood pressure who possess a gene variant that affects an enzyme critical to normal vitamin D activation are twice as likely as those without the variant to have congestive heart failure. \u201cThis study is the first indication of a genetic link between vitamin D action and heart disease,\u201d says Robert U. Simpson, professor of pharmacology at the University of Michigan Medical School and one of the authors of the study in the journal Pharmacogenomics. \u201cThis study revealed that a critical enzyme absolutely required for production of the vitamin D hormone has a genetic variant associated with the development of congestive heart failure,\u201d Simpson says. \u201cIf subsequent studies confirm this finding and demonstrate a mechanism, this means that in the future, we may be able to screen earlier for those most vulnerable and slow the progress of the disease.\u201d Such a screening test would be years away. Study co-authors Russel A. Wilke of the Medical College of Wisconsin and Catherine A. McCarthy of the Marshfield Clinic Research Foundation in Marshfield, Wis., analyzed the genetic profiles of 617 subjects from the Marshfield Clinic Personalized Medicine Project, a large DNA biobank. They looked for variants in five candidate genes chosen for their roles in vitamin D regulation and hypertension. One-third of the subjects had both hypertension and congestive heart failure, one-third had hypertension alone and one-third were included as healthy controls. The results showed that a variant in the CYP27B1 gene was associated with congestive heart failure in patients with hypertension. It is already known that mutations that inactivate this gene reduce the required conversion of vitamin D into an active hormone. \u201cThis initial study needs to be confirmed with a larger study that would permit analysis of the full cardiovascular profile of the population possessing the gene variant,\u201d Simpson says. A future study also would need to include people of more diverse origins than this study\u2019s population of mostly European ancestry, the authors say. Citation: Pharmacogenomics, (2009) 10(11):1789-97 Additional authors: Bikol N. Mukesh, Satya V. Bhupathi, Richard A. Dart and Nader R. Ghebranious, Center for Human Genetics, Marshfield Clinic Research Foundation Funding: National Institutes of Health, Marshfield Clinic Personalized Medicine Research Project, Michigan Institute for Clinical and Health Research Patents\/conflict disclosures: The research was funded in part by donors to cardiology research at Marshfield Clinic. Robert Simpson has a financial interest in and is president of Cardiavent, Inc., a company that is developing an analog (CARDO24) of vitamin D to treat cardiovascular diseases.","og_url":"https:\/\/news.smarttan.com\/index.php\/another-study-shows-that-vitamin-d-reduces-the-risk-of-heart-failure\/","og_site_name":"Smart Tan News","article_publisher":"https:\/\/www.facebook.com\/SmartTan","article_published_time":"2009-12-03T07:59:26+00:00","article_modified_time":"2011-10-31T16:23:47+00:00","og_image":[{"url":"https:\/\/smarttan.com\/blog\/wp-content\/uploads\/2009\/12\/2009-12-02-d-for-heart-health-tanningnews-copy.thumbnail.jpg","type":"","width":"","height":""}],"author":"smarttan","twitter_card":"summary_large_image","twitter_creator":"@SmartTan","twitter_site":"@SmartTan","twitter_misc":{"Written by":"smarttan","Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/news.smarttan.com\/index.php\/another-study-shows-that-vitamin-d-reduces-the-risk-of-heart-failure\/#article","isPartOf":{"@id":"https:\/\/news.smarttan.com\/index.php\/another-study-shows-that-vitamin-d-reduces-the-risk-of-heart-failure\/"},"author":{"name":"smarttan","@id":"https:\/\/news.smarttan.com\/#\/schema\/person\/4191f4b1131c0a37b4fd39f876771e7b"},"headline":"Another study shows that vitamin D reduces the risk of heart failure","datePublished":"2009-12-03T07:59:26+00:00","dateModified":"2011-10-31T16:23:47+00:00","mainEntityOfPage":{"@id":"https:\/\/news.smarttan.com\/index.php\/another-study-shows-that-vitamin-d-reduces-the-risk-of-heart-failure\/"},"wordCount":453,"publisher":{"@id":"https:\/\/news.smarttan.com\/#organization"},"image":{"@id":"https:\/\/news.smarttan.com\/index.php\/another-study-shows-that-vitamin-d-reduces-the-risk-of-heart-failure\/#primaryimage"},"thumbnailUrl":"https:\/\/smarttan.com\/blog\/wp-content\/uploads\/2009\/12\/2009-12-02-d-for-heart-health-tanningnews-copy.thumbnail.jpg","articleSection":["News"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/news.smarttan.com\/index.php\/another-study-shows-that-vitamin-d-reduces-the-risk-of-heart-failure\/","url":"https:\/\/news.smarttan.com\/index.php\/another-study-shows-that-vitamin-d-reduces-the-risk-of-heart-failure\/","name":"Another study shows that vitamin D reduces the risk of heart failure - Smart Tan News","isPartOf":{"@id":"https:\/\/news.smarttan.com\/#website"},"primaryImageOfPage":{"@id":"https:\/\/news.smarttan.com\/index.php\/another-study-shows-that-vitamin-d-reduces-the-risk-of-heart-failure\/#primaryimage"},"image":{"@id":"https:\/\/news.smarttan.com\/index.php\/another-study-shows-that-vitamin-d-reduces-the-risk-of-heart-failure\/#primaryimage"},"thumbnailUrl":"https:\/\/smarttan.com\/blog\/wp-content\/uploads\/2009\/12\/2009-12-02-d-for-heart-health-tanningnews-copy.thumbnail.jpg","datePublished":"2009-12-03T07:59:26+00:00","dateModified":"2011-10-31T16:23:47+00:00","description":"DEC. 2, 2009 (UNIVERSITY OF MICHIGAN PRESS RELEASE) \u2014 Previous studies have shown a link between low vitamin D status and heart disease. Now a new study shows that patients with high blood pressure who possess a gene variant that affects an enzyme critical to normal vitamin D activation are twice as likely as those without the variant to have congestive heart failure. \u201cThis study is the first indication of a genetic link between vitamin D action and heart disease,\u201d says Robert U. Simpson, professor of pharmacology at the University of Michigan Medical School and one of the authors of the study in the journal Pharmacogenomics. \u201cThis study revealed that a critical enzyme absolutely required for production of the vitamin D hormone has a genetic variant associated with the development of congestive heart failure,\u201d Simpson says. \u201cIf subsequent studies confirm this finding and demonstrate a mechanism, this means that in the future, we may be able to screen earlier for those most vulnerable and slow the progress of the disease.\u201d Such a screening test would be years away. Study co-authors Russel A. Wilke of the Medical College of Wisconsin and Catherine A. McCarthy of the Marshfield Clinic Research Foundation in Marshfield, Wis., analyzed the genetic profiles of 617 subjects from the Marshfield Clinic Personalized Medicine Project, a large DNA biobank. They looked for variants in five candidate genes chosen for their roles in vitamin D regulation and hypertension. One-third of the subjects had both hypertension and congestive heart failure, one-third had hypertension alone and one-third were included as healthy controls. The results showed that a variant in the CYP27B1 gene was associated with congestive heart failure in patients with hypertension. It is already known that mutations that inactivate this gene reduce the required conversion of vitamin D into an active hormone. \u201cThis initial study needs to be confirmed with a larger study that would permit analysis of the full cardiovascular profile of the population possessing the gene variant,\u201d Simpson says. A future study also would need to include people of more diverse origins than this study\u2019s population of mostly European ancestry, the authors say. Citation: Pharmacogenomics, (2009) 10(11):1789-97 Additional authors: Bikol N. Mukesh, Satya V. Bhupathi, Richard A. Dart and Nader R. Ghebranious, Center for Human Genetics, Marshfield Clinic Research Foundation Funding: National Institutes of Health, Marshfield Clinic Personalized Medicine Research Project, Michigan Institute for Clinical and Health Research Patents\/conflict disclosures: The research was funded in part by donors to cardiology research at Marshfield Clinic. Robert Simpson has a financial interest in and is president of Cardiavent, Inc., a company that is developing an analog (CARDO24) of vitamin D to treat cardiovascular diseases.","breadcrumb":{"@id":"https:\/\/news.smarttan.com\/index.php\/another-study-shows-that-vitamin-d-reduces-the-risk-of-heart-failure\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/news.smarttan.com\/index.php\/another-study-shows-that-vitamin-d-reduces-the-risk-of-heart-failure\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/news.smarttan.com\/index.php\/another-study-shows-that-vitamin-d-reduces-the-risk-of-heart-failure\/#primaryimage","url":"https:\/\/smarttan.com\/blog\/wp-content\/uploads\/2009\/12\/2009-12-02-d-for-heart-health-tanningnews-copy.thumbnail.jpg","contentUrl":"https:\/\/smarttan.com\/blog\/wp-content\/uploads\/2009\/12\/2009-12-02-d-for-heart-health-tanningnews-copy.thumbnail.jpg"},{"@type":"BreadcrumbList","@id":"https:\/\/news.smarttan.com\/index.php\/another-study-shows-that-vitamin-d-reduces-the-risk-of-heart-failure\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/news.smarttan.com\/"},{"@type":"ListItem","position":2,"name":"Another study shows that vitamin D reduces the risk of heart failure"}]},{"@type":"WebSite","@id":"https:\/\/news.smarttan.com\/#website","url":"https:\/\/news.smarttan.com\/","name":"Smart Tan News","description":"","publisher":{"@id":"https:\/\/news.smarttan.com\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/news.smarttan.com\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/news.smarttan.com\/#organization","name":"Smart Tan","url":"https:\/\/news.smarttan.com\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/news.smarttan.com\/#\/schema\/logo\/image\/","url":"https:\/\/smarttan.com\/news\/wp-content\/uploads\/2022\/08\/Smart-Tan.png","contentUrl":"https:\/\/smarttan.com\/news\/wp-content\/uploads\/2022\/08\/Smart-Tan.png","width":500,"height":164,"caption":"Smart Tan"},"image":{"@id":"https:\/\/news.smarttan.com\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/SmartTan","https:\/\/x.com\/SmartTan"]},{"@type":"Person","@id":"https:\/\/news.smarttan.com\/#\/schema\/person\/4191f4b1131c0a37b4fd39f876771e7b","name":"smarttan","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/60bebff64d4c62315967b9126de927b81d5a9d9511fd52f9dbe9e8b344149182?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/60bebff64d4c62315967b9126de927b81d5a9d9511fd52f9dbe9e8b344149182?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/60bebff64d4c62315967b9126de927b81d5a9d9511fd52f9dbe9e8b344149182?s=96&d=mm&r=g","caption":"smarttan"},"url":"https:\/\/news.smarttan.com\/index.php\/author\/smarttan\/"}]}},"_links":{"self":[{"href":"https:\/\/news.smarttan.com\/index.php\/wp-json\/wp\/v2\/posts\/2750","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/news.smarttan.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/news.smarttan.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/news.smarttan.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/news.smarttan.com\/index.php\/wp-json\/wp\/v2\/comments?post=2750"}],"version-history":[{"count":1,"href":"https:\/\/news.smarttan.com\/index.php\/wp-json\/wp\/v2\/posts\/2750\/revisions"}],"predecessor-version":[{"id":6867,"href":"https:\/\/news.smarttan.com\/index.php\/wp-json\/wp\/v2\/posts\/2750\/revisions\/6867"}],"wp:attachment":[{"href":"https:\/\/news.smarttan.com\/index.php\/wp-json\/wp\/v2\/media?parent=2750"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/news.smarttan.com\/index.php\/wp-json\/wp\/v2\/categories?post=2750"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/news.smarttan.com\/index.php\/wp-json\/wp\/v2\/tags?post=2750"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
DEC. 2, 2009 (UNIVERSITY OF MICHIGAN PRESS RELEASE) \u2014 Previous studies have shown a link between low vitamin D status and heart disease. Now a new study shows that patients with high blood pressure who possess a gene variant that affects an enzyme critical to normal vitamin D activation are twice as likely as those […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-2750","post","type-post","status-publish","format-standard","hentry","category-news"],"yoast_head":"\n